Taking CBD or marijuana might help your pain, but could be making the other drug(s) you’re taking more toxic.
It is widely known that cannabis has many medicinal benefits, with managing chronic pain, epilepsy, anxiety and treating the symptoms of PTSD among them.
However, in the case of cannabinoids, a group of substances found in the cannabis plant, there is a risk that combining it with other prescription drugs could pose harmful drug-drug interactions, suggests new research undertaken by scientists at Washington State University (WSU).
The findings examined the interaction between three of the most abundant cannabinoids – tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabinol (CBN).
“Physicians need to be aware of the possibility of toxicity or lack of response when patients are using cannabinoids,” said Philip Lazarus, senior author on the paper and Boeing distinguished professor of pharmaceutical sciences. “It’s one thing if you’re young and healthy and smoke cannabis once in a while, but for older people who are using medications, taking CBD or medicinal marijuana may negatively impact their treatment.”
The Findings
Researchers used manipulated human kidney cells and confirmed their results in human liver and kidney specimens in which enzymes were present.
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