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Marijuana users' risk of deadly complication doubles after rare type of bleeding stroke

Among people with an aneurysmal subarachnoid hemorrhage (aSAH) stroke, a type of bleeding stroke, recent marijuana users were more than twice as likely to develop a dangerous complication that can result in death or greater disability, according to new research published today in Stroke, a peer-reviewed journal of the American Stroke Association, a division of the American Heart Association.

The study is the largest to examine the impact of THC or Tetrahydrocannabinol, the psychoactive component (change of a person's mental state) of marijuana on complications after an aneurysmal subarachnoid hemorrhage (a severe form of stroke).
 
In an aneurysmal subarachnoid hemorrhage, a weakened and bulging part of a blood vessel bursts on the surface of the brain (called a ruptured aneurysm), resulting in bleeding in the space between the brain and the tissue that covers it. This type of stroke can be devastating, resulting in neurological disability in about 66% of people and death (during the follow up period) in about 40%. The immediate treatment of an aneurysmal subarachnoid hemorrhage focuses on stopping and preventing further bleeding. However, despite treatment, in the 14 days following an aneurysmal subarachnoid hemorrhage, many patients may develop worsening symptoms (such as speech problems or difficulty moving). This is caused by blood from the initial stroke irritating blood vessels, causing them to constrict enough to cut off the blood supply to a portion of the brain (called a vasospasm), resulting in more brain damage. This complication, called delayed cerebral ischemia, is a leading cause of death and disability after an aSAH stroke.

"We're all vulnerable to a bleeding stroke or a ruptured aneurysm, however, if you're a routine marijuana user, you may be predisposed to a worse outcome from a stroke after the rupture of that aneurysm," said Michael T. Lawton, M.D., senior author of the study and president and CEO of Barrow Neurological Institute in Phoenix, Arizona.

Researchers analyzed data on more than 1,000 patients who had been treated for aneurysmal subarachnoid hemorrhage at Barrow Neurological Institute between January 1, 2007 to July 31, 2019. All patients had been treated to stop the bleeding either via 1) open surgery to clip off the base of the aneurysm, or, 2) noninvasively, by threading a slim tube through a blood vessel to the base of the aneurysm and releasing coils that fold to fill in the space and provide a barrier to further bleeding.

Urine toxicology screening was performed on all patients admitted with ruptured aneurysms. The study compared the occurrence of delayed cerebral ischemia in 46 people (average age of 47 years; 41% female) who tested positive for THC (the component of cannabis, also known as marijuana, that induces a high) and 968 people (average age 56 years, 71% female) who tested negative for THC. A positive urine screen for THC reflects cannabis exposure within three days for a single use to within approximately 30 days for frequent heavy use.
 
The recent cannabis users did not have significantly larger aneurysms or worse stroke symptoms when admitted to the hospital, and they were not more likely to have high blood pressure or other cardiovascular risk factors than patients who screened negative for THC. However, recent cannabis users were significantly more likely to have also tested positive for other substances, including cocaine, methamphetamines and tobacco, compared to the patients who screened negative for THC.

Among all participants, 36% developed delayed cerebral ischemia; 50% were left with moderate to severe disability; and 13.5% died.

After adjusting for several patient characteristics as well as recent exposure to other illicit substances, patients who tested positive for THC at last follow up were found to be:

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Highway to Hemp: ‘Wild West’ of the CBD Market

Industry Waits On FDA Approval To Reach Its Full Potential, But Producers Are Still Hopeful

Across the country, bags of hemp grown as long ago as 2019 still sit in barns, waiting to be sold and extracted. 

When the 2018 Farm Bill legalized industrial hemp, most growers grew hemp for cannabidiol (CBD) extraction, because it had a high profit-to-acreage ratio. With an estimated 455% increase in U.S. hemp producers, the CBD industry quickly found itself with a glut of product and not enough consumer demand. Moreover, there wasn’t enough processing capacity to make the crop profitable. 

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COVID-19, Cannabis & Culture: The Rapid Evolution of Employment Law

 

 

When discussing employment law in 2022, it is important to first consider its fluidity.

“What we’ve said today could change tomorrow,” says Catherine Wells, member and chair of the Chiesa, Shahinian & Giantomasi P.C. Employment Law Group in West Orange.

“Employers need to ensure they remain mindful and updated on all of the changes in the law to remain compliant,” adds Joshua Weiner, partner and co-chair of the Lindabury, McCormick, Estabrook & Cooper P.C. Employment and Labor Law Group in Westfield.

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Is Big Pharma Weed Coming With Pfizer’s Recent Purchase?

Pfizer wants in on the cannabis game. Will you be buying Pharma Weed? Most consumers say absolutely not.

You may not have heard the wonderful news. Our great overlords and global saviors at Pfizer announced their intentions to get into the medical cannabis market via their $6.7 billion acquisition of Arena Pharmaceuticals Inc. Of course, the giant pharmaceutical company has a lot of “expendable cash” available due to the pandemic.

However, the news of Pfizer wanting to break into the medical cannabis industry isn’t something new. Every advocate understood that once cannabis is legalized globally, these giant pharmaceutical companies would definitely make their claim to some portion of the marketplace. Whether this is a “good” thing or a “bad” thing is irrelevant; the truth of the matter is that pharma entering into the cannabis industry is an inevitability.

Putting my personal prejudices aside for a moment, along with some of the more atrocious historical facts of the company, perhaps this could be the dawn of the next wave of cannabinoid medicines. While some might cringe at the idea of pharma handling this sacred plant, cannabinoid-based medicines will evolve into more standardized packaging. It will eventually become dose specific and potentially a robust cannabinoid treatment protocol for a large group of conditions.

For that to happen, pharma has to dig their money-hungry hands into the market and begin to do some R&D. In the case of their recent acquisition, we can already see that they are targeting specific conditions and will be creating a medication instead of trying to sell tinctures, whole plant, etc.

Benzinga reported on the acquisition:
 
“The proposed acquisition of Arena complements our capabilities and expertise in Inflammation and Immunology, a Pfizer innovation engine developing potential therapies for patients with debilitating immuno-inflammatory diseases with a need for more effective treatment options,” stated Mike Gladstone, global president & general manager, Pfizer Inflammation and Immunology.
 
“Utilizing Pfizer’s leading research and global development capabilities, we plan to accelerate the clinical development of etrasimod for patients with immuno-inflammatory diseases.”
 
Etrasimod is Arena’s drug candidate for the treatment of immune-mediated and inflammatory diseases.

This type of cannabinoid medicine would be able to be obtained via health insurance, meaning that it could make cannabinoid-based medicines widely available for people who may need it.

What’s Some Good That Can Come From This?

While it’s probably easier to pander to the masses and frame Pfizer as the devil incarnate, they too are simply a force of reality that exists and behaves according to its own self-preservation. If they are about making profits, then they will adapt to the market needs and if endocannabinoid-treatment options will become a thing, then their self-preservation would create a net-benefit.

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Is Big Pharma Weed Coming With Pfizer’s Recent Purchase?

Pfizer wants in on the cannabis game. Will you be buying Pharma Weed? Most consumers say absolutely not.

You may not have heard the wonderful news. Our great overlords and global saviors at Pfizer announced their intentions to get into the medical cannabis market via their $6.7 billion acquisition of Arena Pharmaceuticals Inc. Of course, the giant pharmaceutical company has a lot of “expendable cash” available due to the pandemic.

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Clark County preparing for cannabis lounges

Clark County officials are closely monitoring the state’s efforts to regulate cannabis consumption lounges, a process that will largely inform how the county sets its own expectations for the marijuana industry’s expansion.

When they open this year in Nevada as expected, following approval in the state Legislature last summer, lounges will provide locals and tourists with places to consume marijuana. But first, the state’s Cannabis Compliance Board must finalize regulations, which local jurisdictions may then strengthen if they wish.

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Curaleaf vs. Trulieve: Which Cannabis Company Will Generate More Revenue in 2022?

Trulieve's acquisition of Harvest Health puts it in a neck-and-neck race with Curaleaf.

Today, two of the top companies in the marijuana industry are Curaleaf Holdings (OTC:CURLF) and Trulieve Cannabis (OTC:TCNNF). Both are cannabis producers with a presence in many states across the country, and they generated similar revenue in their most recent quarterly results. Trulieve has gotten a big boost due to its recent acquisition of Harvest Health, which closed last year and gave the company many more growth opportunities.

Below, I'll look at which business will likely bring in more revenue in 2022. That could be key in determining which stock generates better returns for its investors.

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38 companies want Coshocton medical marijuana dispensary

If dispensary is awarded, it will be at the former Family Video on Second Street.

Almost 40 companies have filed for a medical marijuana dispensary license for a facility to be located in Coshocton. The Ohio Board of Pharmacy recently released the company names and addresses for 1,462 applicants for 73 dispensary licenses to be awarded in the coming months.

About 230 entities submitted applications, with 16 submitting more than 10 applications each. A district containing Coshocton, Muskingum and Morgan counties was fifth overall with 101 licenses applied for, 38 were in Coshocton. Application cost was $5,000 each. 

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County Attorney warns Delta-8 illegal; pulled from stores

In the last year, a new product popped up in stores across Ellis County.

Found on shelves in local convenience and liquor stores, Delta-8 products were being sold in a variety of forms, from edible to vape-based.

Often found near CBD or nicotine-based products, Delta-8 has been readily available for months across the state.

But while the product was being openly purchased and consumed, recent guidance from the Ellis County Attorney and Kansas Attorney General Derek Schmidt clarified Delta-8 is illegal to sell and possess in Kansas.

After informing area businesses of the new clarification, most shops in the county have removed the product from their shelves, but now Ellis County Attorney Robert Anderson, warned those that continue to sell or possess the product are now in clear violation of the law.

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What 2021 Taught Us About Young People And Cannabis Use

Medical and cannabis professionals wouldn’t confirm that teen use was in the downturn, however, 2021 offered substantial studies  to suggest that may be the case.

The possible effects of cannabis on young people will continue to be of the utmost concern as the legal marketplace takes shape. Throughout 2021, several studies helped further comprehension of an area that still suffers from a significant education gap.

While nothing became definitive in 2021, research helped advance understanding for several critical areas.

Legalization Seemingly Not Increasing Teen Use

Minors don’t appear to be using cannabis more as states legalize — or at all in some cases.

Medical and cannabis professionals wouldn’t confirm that teen use was in the downturn, however, 2021 offered substantial studies and additional comments to suggest that may be the case.

A September 2021 study of high school use between 1993 and 2019 used the Youth Risk Behavior Survey (YRBS) to determine that adult-use laws did not increase teen use. After two years, states with adult-use laws saw decreases in usage.

Substance Abuse and Mental Health Services Administration (SAMHSA) released its annual health and drug use survey from the National Survey on Drug Use and Health (NSDUH). The October 2021 report saw usage among minors aged 12-17 drop from 13% to 10% in 2020–however, the decline could be associated with research methodology changes due to the pandemic. Nearly 50 million (49.6 million) Americans in the age group reported using cannabis during the analysis period.

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Curbside service rules may change for marijuana businesses

Big Rapids officials consider changes to ordinance

Big Rapids city commissioners are considering changes to the city's marijuana ordinance that could eliminate curbside service for businesses in the downtown area.

During a meeting this week, community development director Paula Priebe told the board there is a proposed substantive change to the marijuana ordinance regarding curbside sales and dispensing that she wanted to present to the board for feedback.

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$200M Cannabis and Marijuana Lending Fund Established by the StandardC Network

 StandardC, a leader in cannabis & marijuana banking and financial services, announced today that its lending partner had closed the first $5 million loan from their newly established $200M fund for a leading marijuana cultivator using the StandardC platform.  This partner has extensive experience in the cannabis lending industry, facilitating real estate loans and deploying growth capital for companies like Harborside, Caliva, and other multi-state operators (MSOs). 

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With opt-out deadline in the rearview, municipalities await NYS marijuana regulations

The deadline has passed for municipalities in New York State to opt out of recreational marijuana sales and consumption. Over 600 have said no to dispensaries, and over 700 say they will not allow consumption sites as of now.

Rensselaer Mayor Mike Stammel said his city has not opted out of either opportunity, and he is excited about the economic growth recreational marijuana will bring.

“We are a city that doesn’t have a lot of economic type business that fosters a lot of taxes for us, so something like that probably would,” he explained, “especially a growing facility.”

In August the city council approved for a former storage facility to be a marijuana cultivation and manufacturing plant. While the city hasn’t opted out of consumption sites, Stammel believes focusing on growing is more important. Now, he is waiting for the state to get the ball rolling more quickly on opening up the market.

Heather Trela from the Rockefeller Institute of Government has been working on a database that keeps track of which municipalities across the state are opting out. For those choosing “no,” Trela believes more information from the state might change their minds to opt in at a later date.

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Fugitive located amid marijuana hospitalization, MNPD says

A fugitive was taken into custody Sunday after officials learned he was wanted across multiple states while he was taken into medical care.

According to an arrest warrant, officers responded to West Trinity Lane after Kenneth Johnson, 29, reported he was feeling ill due to smoking marijuana. Officials said he was taken to TriStar Skyline Medical Center where he was treated.

During this time, police said a records check of Johnson’s name and social security number showed he had two outstanding failure to appear warrants, and that he was wanted by U.S. Marshals in Arlington, Virginia.

After being discharged from the hospital, police said they searched Johnson and found 7.3 grams of marijuana in his pocket.

He is now faced with four separate charges.

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Lamborghini Races Into Cannabis Game with CBD-Infused Coffee

Get your engine started with a cup of Lambo-branded, CBD-spiked coffee.

Lamborghini’s “Tonino Lamborghini” lifestyle brand has emblazoned the Raging Bull badge on watches, shades, bags, and now, CBD-infused coffee. Autoevolution reports that the Italian marque’s merchandizing arm is joining forces with Canadian cannabis company Flora Growth to bring coffee infused with the non-psychoactive cannabinoid to market.

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Marijuana withdrawal gives Logan Paul a nightmare Christmas

YouTuber stopped consuming the substance on Christmas Eve

YouTube star Logan Paul has revealed his Christmas Day ordeal, after he decided to quit smoking marijuana.

The 26-year-old posted a message on social media about his nightmarish festive period, going into detail for his 21 milliion followers.
 
 "I quit smoking [weed] on December 24, been having some pretty nasty withdrawals (loss of appetite, insomnia, extreme irritability) - by far the hardest week of 2021 for me," Paul said in an Instagram post.
 
His end of year struggles didn't end with his Christmas Day problems, though. He revealed in the same post that he endured food poisoning on New Year's Day that required him to call for an ambulance.

"I got food poisoning (which was odd because all I had was a tiny croissant & a latte in the morning)," he wrote.

"I threw up 40+ times and spent the evening sweating in bed.

"I was so dehydrated that I begged the only emergency ambulance in the city to hook me up to an IV so I could replenish and go out with my friends. They said it wasn't possible unless they took me to the hospital. Obviously f**k that."

"I managed to put on my suit and go to the party for 10 minutes before I realised my fate was sealed.

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Beto O'Rourke's blunt support of marijuana legalization gives advocates hope for policy change

A race starting in Houstonians' livings rooms could set the stage for one of the state's most expensive gubernatorial races ever.

At a crowded rally in downtown Austin, Beto O'Rourke ticked off his usual laundry list of campaign promises: stabilizing the power grid, rolling back the state's new permitless carry law and expanding health care access.
But the El Paso Democrat got some of the loudest cheers of the night when he promised to legalize marijuana in Texas, something he said "most of us, regardless of party, actually agree on."
 
"I've been warned that this may or may not be a popular thing to say in Austin, Texas," O'Rourke said to the crowd gathered in Republic Square Park in December.
 
"But when I am governor, we are going to legalize marijuana."
 
The support is nothing new for the gubernatorial candidate. O'Rourke has championed legalization efforts throughout his political career, ever since his time as a member of the El Paso city council. He also nodded at the policy throughout his failed campaigns for U.S. Senate and for president.

But in his early run for governor, O'Rourke, who declined to be interviewed for this story, has repeatedly mentioned legalizing marijuana on the campaign trail across Texas. Advocates hope the increased attention will give momentum to legalization efforts in a state with some of the harshest penalties and highest arrest rates for marijuana possession.

O'Rourke's advocacy around the issue dates back at least to his time on the El Paso City Council in 2009 when he pushed for a resolution calling on Congress to have "an honest, open national debate on ending the prohibition" of marijuana.

Despite unanimously passing the city council, then-Mayor John Cook vetoed the nonbinding measure. Cook got some help from then-U.S. Rep. Silvestre Reyes, who warned council members the city could lose federal funds if they continued with their effort.

O'Rourke went on to challenge and defeat Reyes in the 2012 Democratic primary for his congressional seat. During that race, Reyes released an ad attacking O'Rourke's position on marijuana legalization.

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Fewer People Charged For Weed Possession In Ireland Due To New Warning Scheme

According to the College of Psychiatrists in Ireland, some 45,000 people between the ages of 15 and 34 meet the criteria for marijuana dependence.

In 2021, fewer people in Ireland were charged or issued a summons for possessing drugs following the introduction of a new scheme that allows for cannabis possession to be treated with a warning, reported The Irish Times.

According to Garda Press Office’s figures, as of December 14, 2021, up to 5,957 people were either charged or issued a summons in connection to drug possession for personal use compared to 11,127 in 2020 and 9,923 in 2019. This means that the number of people charged was nearly halved.

The expansion of the Adult Cautioning Scheme covering section 3 of the Misuse of Drugs Act (regarding possession of illegal drugs) only covered simple marijuana possession. The cautioning scheme is run by An Garda Síochána (the Irish police dept.) along with the Office of the Director of Public Prosecutions was extended across possession of cannabis for personal use, trespassing, trading without permission and laws relating to specific events, according to the Times.

These changes in the number of people charged for possessing marijuana come “against an international trend towards legalization, but also warnings from the psychiatric profession as to the harmful effects of the drug.”

When it comes to Europe, last year, Malta became the first country in the EU to legalize marijuana, Germany recently announced plans to legally allow weed sales, which will establish the biggest EU market with $3.5 billion in expected annual tax revenue. Switzerland launched a legal adult-use cannabis market trial to study for future regulation.

 

Irelands’ Psychiatrists Warn About Potency 

In 2021, the College of Psychiatrists in Ireland warned that increasingly high potency of marijuana and widespread belief the plant is harmless was generating “devastating effects.”

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Democrats and Republicans need cannabis to exorcise the ghosts of elections past

You may have noticed both U.S. political parties are currently haunted. The apparitions? Ghosts of elections past.

For Republicans, the specter of 2020 has been very publicly conjured by a presidential candidate who will not admit defeat. Meanwhile, Democrats are more quietly suffering visions from 2010, when the passage of the Affordable Care Act, a historic yet complex technocratic achievement—much like the recent infrastructure bill—was followed closely by devastating midterm losses. 

As it stands today, Republicans are doing the better job of exorcising their electoral demons, with Glenn Youngkin’s victory in Virginia as perhaps the most stunning example. The challenge now is President Biden’s, to deliver a common sense, easy-to-understand victory for the American people in time for 2022. He has a clear opportunity in cannabis legislation. 

If we could, like Ebenezer Scrooge from A Christmas Carol, make phantom visits to the dinner tables of present-day voters, we would see how average Americans are struggling with the contradictions of today’s cannabis policies. 

We’d hear the confusion. How can nearly half the U.S. population live in states with legal access to cannabis, while 66 million Americans still suffer the enduring consequences of cannabis-related arrest records?
We’d hear the frustration. Why can a seriously ill individual get relief from medical cannabis at home, but not legally take their medical supply on holiday to one of the remaining restrictive states? With Alabama recently becoming the 36th state to permit medical cannabis, why can’t the nation admit the debate is essentially over? 
 

We’d hear the outrage. How can this nation continue to tolerate the impacts of unfairly targeted cannabis enforcement, which falls heavily on people of color and undermines their employment, education, and housing opportunities—often forever?

But mostly, we’d hear the anger at Washington. Why can’t leaders deliver a rational, consistent, nationwide cannabis policy? Why the constant gridlock? Why the harmful holdup? Both parties would be rewarded for achieving cannabis reform.

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Ramone Martinez: Cannabis tycoon accused of kidnapping and torturing woman to make her 'love him'

Ramone Marcio Martinez, 39, of Salt Lake City, carved the number 6 into the woman's left hand to remind her she had 6 months to 'love him or be killed'

A self-proclaimed Utah “millionaire” is accused of kidnapping a woman and holding her captive in his home for weeks. He reportedly beat her repeatedly and carved the number six into her hand — a reminder that the victim had a six-month deadline to “love him or be killed.”

On December 29, Ramone Marcio Martinez, 39, of Salt Lake City, was arrested and charged with aggravated kidnapping, assault, and five counts of aggravated assault in the case, which is being classified as domestic violence, according to local reports. The unidentified victim managed to escape with a single text message to her friend saying she was being held captive. An investigation was launched after the friend alerted the police.“The victim had texted him begging for help and that she was scared for her life,” according to a police booking affidavit, obtained by ABC 4.

Who is Ramone Marcio Martinez?

A LinkedIn profile shows that Martinez is the CEO of Truu Med, a medical cannabis doctor referral service. The company connects patients with doctors that will write a letter on behalf of the patient. Last year, he appeared on a local news outlet to discuss his business.

In 2019, he gave an interview to CBS affiliate KUTV regarding the regulation of the medical cannabis industry in Utah. "We welcome the regulations to come; we don't mind the oversight whatsoever," he said at the time. Martinez is being held in the Salt Lake County jail. 

Martinez tortured victim for weeks

When the police responded by going to Martinez's home in the Poplar Grove neighborhood, he reportedly "had his hand in his hoodie pocket and I could see the outline of a handgun which he was holding onto."

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