WeedLife News Network

Too often, we hear, "I have been taking CBD, but I don't feel any effects."

But the problem doesn't lie with CBD. Scientific research tells us that cannabinoids (CBD, THC, CBG, CBN) provide therapeutic relief relating to stress, anxiety, sleeplessness, and inflammation with the right dose and when taken correctly. Medical marijuana shows even greater promise for more severe ailments like epilepsy, Alzheimer's, Parkinson's, and cancer, to name a few.

The issue stems from CBD's inability to absorb easily into the body; more biotechnological advances are necessary to resolve this. Cannabinoids are oil-based and do not readily absorb into bodies that are 80% water. Additionally, they face destruction from stomach acid and other obstacles when traveling through the digestive system. Thankfully, there is a flurry of activity among chemists and engineers looking for innovative solutions. 

Let's start with the different ways cannabinoids get processed in our bodies.

The pros and cons 

1.  Nasal spray or vaping provides the most rapid results and CBD intake because it enters directly into the bloodstream through thin membranes of the nose and lungs.

Do cucumbers prefer blue light during flowering?

How is the chemical profile of a cannabis plant influenced by the duration of exposure to infrared light?

Believe it or not, these are the kinds of questions farmers often find themselves asking.

As cannabis research has amped up, cultivators are starting to find the answers they need through scientific research.

Lighting impacts plant quality, harvest size, and flavor profiles, so it makes sense that many indoor growers are creating light strategies for each cultivar.

Cannabis contains more than 100 cannabinoids. However, there are two that are the main and the most popular ones. These two cannabinoids differ in effects and legal status. We talk about THC (Tetrahydrocannabinol) and CBD (Cannabidiol). Each one produces something different and contributes both to the sensation that marijuana produces and its therapeutic applications. Knowing both compounds allows you to better choose the variety when growing, as well as knowing what to look for according to whether you want something recreational or medicinal. The other components can also influence our body, but they are more difficult to isolate and we know less about their possible effects.

THC vs CBD

Cannabidiol (CBD) is the second most abundant compound in Cannabis sativa, but that doesn’t make it any less attractive. CBD possesses some unique capabilities that THC cannot match. It is also the main ingredient in CBD oil, an increasingly popular wellness supplement.THC is the main compound in Cannabis sativa. Concentration aside, THC’s fame stems from its psychotropic side effects.

While CBD can influence well-being without major side effects, THC interacts with specific regions of the brain and causes a feeling of euphoria that temporarily affects the way we think and feel. In other words, CBD does not contain any psychoactive component and does not make you high. Many products used to relieve pain or to take care of your skin contain CBD. CBD products, like the purest CBD oil for a healthy lifestyle, are getting more and more popular day by day. In contrast, THC is the principal psychoactive component of the plant.  

Benefits of CBD

Pain Relieving Effect

CBD is incorporated in many products that are used daily. Soaps, lotions, oils, and other skincare goods are highly recommended to relieve pain. People that have used these oils or lotions claim that they felt pain alley nearly immediately after the use. It is believed that CBD containing products reduce muscular, chronic pain, alley painful effects of chemotherapy and similar therapies. 

Reduces Anxiety and Depression

Anxiety and depression have an impact on our mental health causing also physical disorders. CBD containing oils are recommended as an alternative treatment for both depression and anxiety. Many users of CBD oils claim that drugs prescribed to treat anxiety and depression have many side effects, meanwhile, CBD does not have any known negative effect and acts faster than medical drugs. CBD acts on the brain’s receptors for serotonin, a neurotransmitter that regulates mood and social behavior.

Atherosclerosis, often referred to as a hardening of the arteries, is a major issue across the globe. According to at least one study, roughly half of individuals 40-54 years old have hardened arteries.  That is obviously a significant number and includes people that do not smoke and/or are of normal weight.

Hardening of arteries happens when fat and cholesterol (and other substances) build upon the walls of people’s arteries. It’s most common in the heart, but can occur elsewhere. The deposits, commonly referred to as plaques, narrow the artery’s blood flow over time and in some cases completely block the blood flowing through the arteries. Sufferers typically do not experience symptoms until the blood flow starts to be restricted, and common symptoms are chest pain and/or shortness of breath.

Cannabis And Atherosclerosis

Researchers in the United States and Switzerland recently collaborated to explore the relationship between cannabis use and atherosclerosis. According to a peer-reviewed study, tobacco use ‘can damage the function of your heart and the structure and function of your blood vessels’ which increases the chances of developing atherosclerosis.

But what about cannabis?

“This study adds to the growing body of evidence that there might be no association between the average population level of marijuana use and subclinical atherosclerosis,” authors of the new cannabis study concluded. The researchers also found that the cumulative use of tobacco was associated with the hardening of arteries, with an odds ratio of 1.88 compared to 0.87 with cannabis.

The website you’re ordering from should look legitimate, like it was designed in this century, and should also have recommendations from publications and reviews from different customers.

Marijuana’s slow but steady movement towards federal legalization has been heavily documented, gaining support across the nation and with more and more medical and recreational programs gaining approval. But there remains a lot of mystery in the purchase process, with many turning to black market marijuana because it seems simpler and less intimidating than legal weed.

Legal marijuana still has some growing pains, but it has slowly become a simple and more intuitive process. Now, depending on the state where you live, you’re able to purchase marijuana online, at times having it delivered or scheduled for pick-up. Here’s how to buy weed on the web.

Do your research

Photo by Andrea Piacquadio via Unsplash

When ordering marijuana flower and marijuana products, it’s important to account for where you live, since you won’t have access to these services if you live in an illegal state.

The amount of liquid marijuana seized in Japan has been surging, putting police and customs authorities on high alert.

The estimated amount of marijuana in liquid form confiscated by Tokyo Customs in 2020 jumped nearly 70 times from the previous year’s level. A customs official described the situation as “an explosive increase.”

The liquid extracted from marijuana plants has a higher content of hallucinogenic tetrahydrocannabinol, or THC, than dried cannabis and can be used in a similar way to electronic cigarettes.

“Many users are youngsters,” an official at Tokyo’s Metropolitan Police Department said. “My impression is that it has been in wider use for the past 10 years or so.”

According to Tokyo Customs, the liquid marijuana seizure amount was roughly 400 grams for the whole of 2019, but it jumped to some 9 kilograms in the first half of 2020 and to 18 kilograms in the following five months through the end of November.

Not all cannabis testing is equal, but the USA’s National Institute of Standards and Technology (NIST) is aiming for it.

Legally speaking, the only thing distinguishing hemp from marijuana is its THC level. Not so long ago, the presence of any level of THC in cannabis made it marijuana at a federal level in the USA, but the 2018 Farm Bill made hemp with less than 0.3% THC legal.

THC testing can be a particularly difficult task where the cannabinoid is at low levels and one lab’s results may differ from another due to different methods or even just plain old human error. There can be a lot at stake – a farmer’s crop.

“If you’re going to confiscate a farmer’s crop, or subject a person to prosecution, you want to be sure that measurement is accurate,” said NIST research chemist Brent Wilson.

NIST has issued an invitation to labs to participate in a study that will assist them to produce the accurate measurements required to make a reliable call as to whether a cannabis sample is hemp or marijuana.

Did you know that we’re supposed to get 5 to 9 servings of fruit and vegetables every day? This equates to roughly two cups of fruit and 2.5 cups of vegetables. Although this is the recommended amount of fruit and veggies we should eat according to the USDA (United States Dietary Association), most of the American population doesn’t come close to meeting these guidelines.

Fortunately, though, another plant consumed for centuries due to its plethora of medicinal, therapeutic, and nutritional benefits is cannabis. Recently, numerous researchers and physicians have labeled cannabis a superfood, worthy of incorporation into your diet in some way or another. Here’s why.

Medicinal, therapeutic, and nutritional value 

Cannabis’s many medicinal and therapeutic benefits have been well established, but the nutritional benefits of cannabis are still gaining recognition and public coverage. According to the British Dietetic Association (BDA), superfoods are unprocessed foods rich in vitamins, minerals, and nutrients, which are often derived from fruits, vegetables, and other herbs. Under this definition, numerous doctors believe cannabis can be grouped into the ‘superfoods’ category.

Besides cannabis’s array of medicinal and therapeutic benefits, the plant is an excellent source of vitamins and nutrients. In general, there are various parts of cannabis that can be consumed such as its leaves, stems, and buds whether they’re heated up or not. To reap cannabis’s nutritional benefits though, consuming raw parts of the plant is the way to go.

Superfood properties

Cannabis sativa (hemp) seeds:

The U.S. Food and Drug Administration is still inching its way towards developing consumer protection standards relating to CBD.

Back in 2019, it appears it came as a shock to many Americans federal standards for cannabidiol (CBD) hadn’t been developed. The FDA has repeatedly stated this has been due to gaps in its knowledge and it’s a situation that continues today.

But the agency hasn’t quite been sitting on its hands as some might suggest – for example, last year it revealed some interesting results from testing of 147 CBD and hemp products it purchased.

Last week, the FDA provided an update on its efforts to “CBD” (Collect Better Data) on the use of cannabidiol and its safety profile.

While the FDA says it has appreciated input from various parties in helping develop better data on the use and safety of products containing CBD, these efforts are “generally not adequate” – citing observational studies that are too small or using poor techniques for ensuring data quality. But in the months to come, the FDA intends developing and refining plans for research projects to address the gaps in current CBD data research capabilities.

There’s an ancient botanical that millions of Americans take for epilepsy, cancer pain, Parkinson’s disease, post-traumatic stress disorder, multiple sclerosis and other serious and debilitating conditions.

The drug is cannabis. But American researchers who want to study cannabis are thwarted at every turn. Federal law still classifies cannabis as a Schedule 1 drug, a list that includes highly dangerous and addictive drugs such as heroin. The government says cannabis has no accepted medical use and a high potential for abuse. Even cocaine is not a Schedule 1 drug.

The U.S. Drug Enforcement Administration limits research to poor quality cannabis from a sole supplier. Researchers who want to study the cannabis that patients are actually taking today are out of luck.

The majority of Americans now live in a state where medicinal cannabis is legal. Yet objective research into what strains help — or hurt — specific conditions, as well as the best dosages, is hindered by federal restrictions. Don’t blame researchers. Can we expect them to jeopardize their research grants, even their medical licenses, to study cannabis?

The time to change the classification of cannabis and open the door to quality research is now. The U.N. Commission on Narcotic Drugs voted recently to reclassify cannabis. In Washington, D.C., the House of Representatives voted to pass the MORE Act, which would remove cannabis from the Controlled Substances Act. The House also passed the Marijuana Research Act, which would allow scientists to obtain cannabis for research from states that have legalized the drug. Right now, the University of Mississippi is the only federally approved source of cannabis.

The cannabis plant is arguably the most dynamic plant on earth. It can be used for medical purposes, it can be converted into fuel, and it can be made into countless types of textiles.

In many ways it would be easier to come up with a list of things that the cannabis plant cannot do versus compiling a list of everything that it can do.

The cannabis plant’s versatility has been on display for many centuries across the globe, with a number of civilizations incorporating cannabis into their cultures.

It wasn’t until cannabis prohibition was implemented in the 20th century that the human use of cannabis for various purposes started to decline, and with it, humanity’s quest to know more about the cannabis plant.

Prohibition’s Impact On Research

During the 20th century most countries around the world expressly prohibited all things cannabis.

The Hemp Act of 2020 proposes four significant amendments to the federal laws currently governing the production of hemp, including increased THC concentrations.

As reported by Hemp Grower magazine, Senator Rand Paul of Kentucky introduced legislation on December 15 that would amend the definition of hemp from .3% THC to 1% THC. The bill would also make other major changes to the USDA’s interim final rule, which would affect hemp growers, processors, manufacturers, and shippers. The legislation is titled the Hemp Economic Mobilization Act (the “Hemp Act of 2020”). The Hemp Act of 2020 proposes four significant amendments to the federal laws currently governing the production of hemp.

First, the Hemp Act of 2020 would amend the federal definition of hemp by striking “.3 percent” and inserting “1 percent.” As hemp businesses know, the 2018 Farm Bill defines hemp as cannabis sativa with a delta-9 THC concentration of not more than .3 percent on a dry weight basis. The USDA then adopted a “total THC” testing requirement that further burdened growers and others in the industry.

As we wrote back in January 2019, the .3% threshold was created by a Canadian researcher in the 1970s who set a dividing line of .3% between hemp and marijuana for purposes of establishing a biological taxonomy. The dividing line was never intended to be used as a practical measure for countries to differentiate between hemp and marijuana for commercial purposes. We at the Canna Law Blog wholeheartedly support changing the threshold from .3% to 1%.

Second, the Hemp Act of 2020 would require testing of hemp-derived products rather than the hemp flower or plant itself.  The USDA interim rule requires that growers test hemp plants within 15 days of the anticipated harvest. As we have explained, this can prove an impossible obstacle for growers in some circumstances. The Hemp Act of 2020 proposes a significant statutory fix. Current law requires a State or Tribal plan to include a “procedure for testing . . . delta-9 tetrahydrocannabinol concentration levels of hemp produced in the State or territory of the Indian tribe” (italics added). The Hemp Act of 2020 would replace “hemp” with “products derived from hemp plants” (italics added again.)

Rocky Mountain Extraction Services (RMES) has come a long way since incorporating 18 months ago.

The 2018 Hemp Farming Act was the catalyst, although opening their doors wasn’t quite so simple.

“Originally, we felt like [the Hemp Farming Act] was a green light,” says CTO Jerry Van Sickle. “What we found was that it was more of a yellow light.”

Because of hemp’s association with recreational marijuana, Van Sickle and CEO Scott McWhorter discovered challenges in commercial property leasing and banking for RMES — even though they were specializing in manufacturing organically-sourced CBD extracts and distillates rather than THC.

Drug development today is a long, arduous and expensive proposition. Since the first half of the 20th century, the standard of care in medicine and the pharmaceutical industry[1] [2] is developing medications using nationally standardized protocols for medication safety and efficacy along with precision dosing for any new drug. Formulation development of drugs is key to ensure standardized quality, control over precision dosing, safety, accurate quantities delivered as well as the delivery to the correct site of action.

Using botanically derived medicines with their high degree of variability is why most drugs today, despite them being derived originally from compounding natural substances from plants, are now chemically synthetic versions made in laboratories. For example, the drug digitalis (or digoxin) which was originally derived from the foxglove plant[3] is now synthetically made. Cannabis, like many botanicals presents challenges to drug development and formulation. One of the biggest challenges is the ability to fully demonstrate and prove consistency in its chemical composition due in part to its complexity.

Cannabis is composed of over 100 cannabinoids and about 500 other compounds such as terpenes and flavonoids. Additionally, there are over 550 different strains/chemovars of the plant all with differing ratios and combinations of these cannabinoids such as THC and CBD and compounds such terpenes.[4]  And efficacy for one chemovar does not establish efficacy for another due to the interaction of the varied and different ratios of components in each.[5] It practically requires individual testing and proof that each particular chemovar variety of cannabis be evaluated for efficacy for a specific health conditions.

Additionally, the federal illegality of cannabis does not allow for nationally systemized controlled agricultural practices and growth conditions to guarantee more consistency in the final product.  This is left to each separate state’s government requirements, therefore creating overall quality issues that make formulation development difficult but important.

When we look at cannabinoid drug development, accurate dosing is major issue. And since oral administration is usually the preferred route[6] for drug compliance and use, this is the first hurdle to overcome. All cannabinoids are lipophilic and have poor water-solubility[7]. When there is poor water solubility there is potentially slow oral drug absorption and that can cause variable bioavailability, which can become a rate-limiting step to achieve therapeutic plasma concentrations and ensuing pharmacologic response[8].

Australia’s Neurotech International Limited (ASX: NTI) has reported final results of in-vitro studies indicate its DOLCE/NTI cannabis strains exhibit potent anti-inflammatory activity.

Neurotech acquired an exclusive worldwide license to utilise proprietary cannabis strains from Dolce Cann Global, which it hopes could potentially be used to treat neurological disorders including autism, epilepsy and ADHD.

Neurotech’s analysis of 80 cannabis samples from the Dolce Cann Global revealed varying amounts of  cannabinoids including CBDV, CBDA, CBGA, CBG, CBD, THCV, CBN, THC, d8-THC, CBC and THCA – some of the many cannabinoids found in cannabis. CBDA was found to be present in particularly high levels.

The company has been undertaking a series of in-vitro* studies to assess the neuroprotective, anti-inflammatory and neuro-modulatory activities of the strains. Neurotech says the final results indicate DOLCE/NTI strains examined have shown to significantly improve neuronal cell health, cell viability and have the potent ability to reduce inflammation.

“Preclinical studies suggest that these strains exhibit potent and unique properties when compared to CBD alone and warrant the further assessment of these strains in phase 1 clinical trials,” said Assoc. Prof. Fahey.

Unlike the breathalyzer, which can detect alcohol impairment within seconds, Indiana’s new drug test experiment only shows that a motorist has used drugs.

As more states work to loosen their marijuana laws, and in many cases, make it part of legal society, some are still clinging to antiquated Drug War concepts in an attempt to disrupt progress. Indiana is one of those states. Not only are officials refusing to consider legitimizing cannabis for medicinal or recreational purposes, they are also, at the same time, imposing policies that will undoubtedly lead to more marijuana-related arrests.

The state recently announced that law enforcement agencies are now using a new roadside drug detection tool to stop drugged driving. However, the test is seriously flawed and could put innocent people in jail.

More than 50 police forces all over the state (including Evansville, Fort Wayne, Indianapolis, Lake County and Muncie) have started using a roadside drug detection device that can determine, within minutes, whether a person has illegal substances coursing through their veins. 

The device, known as the SoToxa Mobile Test System, is supposed to sniff out drivers high on cocaine, opiates, meth, and, of course, marijuana. The test’s manufacturer touts its ability to flag stoned motorists within five minutes by testing their saliva. The problem with this technology is that it scans explicitly for the presence of illegal drugs, not intoxication, making it possible for more sober motorists throughout Indiana to be prosecuted for stoned driving in 2021.  

Blue Dream, Purple Haze, Girl Scout Cookies, Red Headed Stranger, Acapulco Gold, Fruity Pebbles or Pineapple Express… all classic strain names and all of them meaningless.

“Strain names are absolutely misleading with considerable variation in the same cannabinoid content among different specimens of the same strain. You can get the same color and the same smell, but actually levels of the THC and CBD and some of the other compounds could be quite different,” says Robin Marles, Ph.D., chair of the U.S. Pharmacopeia (USP) Botanical Dietary Supplements and Herbal Medicines Expert Committee.

USP has assembled an expert panel of clinicians, scientists and industry representatives from around the world to provide necessary information and guidance on critical quality attributes, including recommendations for naming , all laid out in an article in the Journal of Natural Products, Cannabis Inflorescence for Medical Purposes: USP Considerations for Quality Attributes.

“USP recommendations are entirely focused on the inflorescence of the cannabis plant, popularly known as the flower or ‘the bud.’ And as with any plant product, the first challenge was to determine how to classify the various varieties and subtypes that are currently in use.” said Ikhlas Khan, Ph.D., USP’s Cannabis Expert Panel chair.

USP has elected to recognize cannabis as a single plant species, Cannabis sativa L., with different varieties or subtypes that can then be classified based on their THC and CBD content. The expert panel provided guidance for organizing the plant material into three “chemotype” categories: THC-dominant, CBD-dominant, or intermediate varieties that contain physiologically meaningful levels of both – intending to give prescribers or consumers greater clarity about what substances they are using.

Cannabidiol (CBD) is arguably the most popular cannabinoid on the planet right now. Whereas THC is associated with intoxication, CBD is not.

That is a significant distinction because while many consumers are fans of THC’s effects, not everyone is.

Someone that has no interest in experiencing the euphoric effects of THC, and thus has avoided consuming cannabis, may still want to experience the wellness benefits of CBD.

The market for CBD is larger than the market for THC. That is not a knock on THC – the market size for THC is massive, and increasing as reform victories pile up across the globe.

With that being said, it is no secret why CBD is growing in popularity at an exponential rate because it is appealing to a wider audience.

The time is nigh for the DEA to cooperate in ensuring that medical marijuana research can move forward. Finally.

On December 3, 2020, MAPS (the Multidisciplinary Association for Psychedelic Studies) issued a press release regarding a lawsuit filed against the DEA and the Attorney General to “compel issuance of licenses to manufacture marijuana for clinical trials and potential FDA approval.” We have written about MAPS and its 35 years of advocacy and engagement with DEA before, and we are big fans of the nonprofit.

The announcement of this lawsuit comes on the heels of the United Nations Commission for Narcotic Drugs (CND) voting to accept the World Health Organization’s (WHO) recommendation to remove cannabis and cannabis resin for medicinal purposes from Schedule IV of the 1961 Single Convention on Narcotic Drugs. The U.S. had already confirmed it would support the WHO recommendation and published a statement about its rationale for the vote:

“The vote of the United States to remove cannabis and cannabis resin from Schedule IV of the Single Convention while retaining them in Schedule I is consistent with the science demonstrating that while a safe and effective cannabis-derived therapeutic has been developed, cannabis itself continues to pose significant risks to public health and should continue to be controlled under the international drug control conventions. Further, this action has the potential to stimulate global research into the therapeutic potential and public health effects of cannabis, and to attract additional investigators to the field, including those who may have been deterred by the Schedule IV status of cannabis.”  

In MAPS’ announcement of the lawsuit, it points out that “[e]fforts to conduct meaningful research into cannabis medicines have been blocked for decades; the continued obstruction is causing suffering for people with serious conditions,” which indicates the timeliness of this lawsuit in relation to the CND’s recent vote. According to MAPS and the lawsuit, the DEA has failed to process more than thirty outstanding applications to develop cannabis for research purposes for more than four years despite administrative guidance. The press release outlines the nature of the lawsuit as follows:

The cannabis industry is booming all over the globe, mostly from a medical cannabis standpoint. 

Dozens of countries now allow some form of legal medical cannabis industry to operate within their borders, and some of those countries also have some type of legal import/export industry.

Adult-use is far more limited.

Only two countries, Uruguay and Canada, allow a legal adult-use industry to operate, and in the case of Uruguay, sales are only allowed for residents.

Fortunately, a number of countries are exploring the idea of full legalization, and multiple countries such as Mexico are working to implement adult-use court-ordered mandates.