University College London researchers have found a single dose of cannabidiol boosts blood flow to an important part of the brain.
The hippocampus is part of the brain’s medial temporal lobe (MTL). It plays important roles in shifting information from short-term memory to long-term memory, and in spatial memory that enables navigation. If the hippocampus is damaged, it can impact a person’s existing memories and their ability to form new memories.
The progressive shrinking of the hippocampus is responsible for the short-term memory loss that accompanies Alzheimer’s Disease, the most common form of dementia affecting up to 70% of all people with dementia.
The non-intoxicating cannabinoid CBD is increasingly being investigated for its potential therapeutic benefits, including improving memory function and how the brain processes emotional memories – but the mechanisms have been unclear. New research from UCL may provide an important hint.
The researchers set out to investigate how CBD influences cerebral blood flow in different regions on the brain involved in memory processing. As part of the investigation, 600mg of oral cannabidiol or a placebo was administered to 15 healthy young adult participants who had little or no history of cannabis use. Using a magnetic resonance imaging (MRI) brain scanning technique called ‘arterial spin labelling’ that measures changes in the blood oxygen levels, the researchers determined CBD significantly increased blood flow in the hippocampus.

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